The Women’s Bone Health Institute

The Surprising Fruit That Strengthens Bones 
(And The Missing Piece Scientists Just Discovered)

By Hannah Delaney | May 2025 | 8-minute read

A new understanding of bone health is emerging—and it changes everything we thought we knew about calcium, vitamin D, and osteoporosis prevention.

For decades, doctors have told women the same thing: take calcium, get vitamin D, do weight-bearing exercise.

 

Simple. Straightforward. Proven.

 

Except it's not working.

 

According to the National Osteoporosis Foundation, more than half of Americans over 50 are living with weakened bones or have already developed osteoporosis—bones so porous they're in danger of fracturing from a fall, a jostle, or even a sneeze.

 

Meanwhile, researchers have been quietly studying something unexpected: a humble dried fruit that seems to do what calcium supplements can't.

The Prune Paradox

Studies at Florida State University revealed something remarkable. 

 

The latest research shows that eating prunes, sometimes called dried plums, can help remedy weak bones.

 

Not a little better. Significantly better.

 

George Mason University researchers discovered why: prunes contain natural compounds called phenolics that influence how bone cells communicate with each other.

What Makes Prunes Work?

Prunes are rich in phenolics. That's what makes them so effective.

 

Phenolics are plant compounds that your body uses for cellular protection and bone support.

Here's how phenolics work:


Your bone cells, both the builders and the breakers, respond to phenolic compounds.


Phenolics help calm the breakdown process. They help support the rebuilding process. They work at the cellular level to protect your bones from excessive loss.

 

Although there's one phenolic compounds in prunes that stands out above the rest for bone health.

It's called resveratrol.


In studies, postmenopausal women who took resveratrol showed improved bone density in their lumbar spine and femoral neck.


Bone breakdown markers decreased by 7.24%. 10-year fracture risk dropped significantly. 

 

But unfortunately it's not that straightforward...

Where Prunes Fail...

Here's the practical reality:


One prune contains approximately 0.5 to 1 mg of resveratrol and phenolic compounds.


To get the clinically studied dose, the amount shown in research to make a real difference in bone density: you'd need roughly 150 mg of resveratrol compounds per day.


That means eating 150 prunes per day. That's approximately 3,000 calories per day from prunes alone.
That's also roughly 700 grams of sugar per day from prunes alone.


Obviously, that's not sustainable or realistic. So even if you're eating prunes regularly, you're getting maybe 8-15% of the phenolic compounds that research shows is needed for significant bone rebuilding.


Prunes may help. But they're not enough. But to understand how women are still getting positive results regardless, you need to understand how your bones actually work.

How Bone Remodelling Works 

(And What Menopause Does To It)

Your bones may not look like it but they are alive and are constantly being broken down and rebuilt.

 

When you’re young, the breakdown and rebuilding crews work in balance.

 

But after menopause, that balance is disrupted.

 

The bone-building cells known as osteoblasts gradually lose the strength to keep up with the osteoclasts which are response for breaking down bone. 

Why Modern Life Makes This Worse

The energy that the bone building cells rely on becomes depleted over time worn down by chronic stress, poor sleep, pollution, environmental toxins, and long periods of inactivity.

 

This molecule, the same fuel that powers every cell in your body is called Nicotinamide Adenine Dinucleotide, better known as NAD+. 

 

By the time a woman reaches 60, her NAD+ levels can drop to nearly half of what they were in youth.

 

Without NAD+, even if you give your bone cells all the calcium and materials they need, they're too tired to build. 

 

That's a bone loss crisis.

Here's What Full NAD+ Activation Does

When your bone enzymes get full NAD+ activation your osteoblasts (bone builders) have the NAD+ they need to rebuild bone efficiently.

 

Your bone remodeling cycle rebalances, even though your estrogen is still low.

 

Now your bones can actually respond to all the other things you're doing right.

 

The calcium you're taking? Your bone enzymes use it completely.

 

The vitamin D you're taking? Your bone enzymes respond to it efficiently.

 

The weight lifting you're doing? Your bones rebuild at the rate your muscles are demanding.

 

The magnesium and K2? They work at full capacity.

 

Everything becomes more effective because your bone enzymes finally have the NAD+ power to respond.

 

This is why some women are seeing real results. Not marginal improvements. 

 

Real improvements in their bone density scans.

That's Why We Recommend  Thryve: Specifically Designed for Post-Menopausal Bone Loss

Thryve wasn't created as a generic bone supplement.

 

It was built specifically to address the unique problem post-menopausal women face:

 

Thryve contains 150 mg of phenolic compounds per serving — including a full clinical dose of resveratrol.

 

That's the amount shown in research to fully activate NAD+ in your bone enzymes.

 

But Thryve doesn't stop there.

Thryve also contains quercetin — which works in those same NAD+ enzymatic pathways to ensure NAD+ is used efficiently and completely in your bone-remodeling process.

 

Together, resveratrol and quercetin fully activate and fully utilize NAD+ in your bone enzymes — the exact activation your post-menopausal bones need.

 

You get it in a concentrated form your body can absorb and use efficiently.

And The Best Part?

 

Thryve's simple and natural formula works at the cellular level, meaning it won’t interfere with any medications, treatments, or supplements you're currently taking. 

 

Thanks to NAD+, your body actually gains the energy it needs to fully utilize your bone-supporting supplements like calcium, magnesium, vitamin D3, and K2 to their full potential.

 

Just three powerhouse ingredients, encased in an easy-to-swallow vegetable capsule. Made here in the USA in an FDA and GMP-registered facility, that will be shipped straight to your door.

The 3 Ingredient Bone Restoration System

With the current production schedule and testing protocols, they can only produce 500 units per month.

 

Last month, they sold out in 28 days. The month before, 14 days. During the holidays, I honestly can't guarantee how long this batch will last.

 

Click the button below to see if Thryve is still available.

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Real Women Share Their Thryve Results

Overall Rating: 4.7/5 stars (Based on 274 reviews)

Even My Hairdresser Noticed!"

Even my hairdresser noticed how great my skin looked and couldn't believe I'm 57 years old. My afternoon fatigue is completely gone—I used to crash every day around 2 PM and now I have steady energy until evening.

Sarah M., 57, Retired Teacher

Verified Buyer

"Natural Energy Without Jitters"

But I must explain to you how all this mistaken idea of denouncing pleasure and praising pain was born and I will give you a complete account of the system, and expound the actual teachings of the great explorer of the truth

Lisa R., 42, Working Mom

Verified Buyer

"Better Sleep, Better Everything"

My sleep tracker shows significant improvement in deep sleep quality. According to my data, I feel like my circadian rhythm is back to a natural state. I've been having trouble sleeping for years due to shift work.

Jennifer T., 48, Nurse

Verified Buyer

"My Skin Texture Is Incredible"

The fine lines around my eyes have visibly softened, and people keep asking what I'm doing differently. I've been taking it for 4 months now and the changes just keep getting better.

Amanda C., 39, Personal Trainer

Verified Buyer

Frequently Asked Questions 

About NAD+ and How It Works

What exactly is NAD+ and why do I need it?

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every single one of your 30 trillion cells. Think of it as the "fuel" that powers your cellular engines (mitochondria), drives DNA repair, and activates longevity proteins called sirtuins.

 

After age 40, your NAD+ levels can drop by up to 50%, which is why you start feeling tired, recovering slower, and aging faster. It's not just "getting older"—your cells are literally running out of fuel.

How is this different from other energy supplements or vitamins?

Most energy supplements rely on stimulants like caffeine that give you a temporary boost followed by a crash. Thryve works at the cellular level to restore your body's natural energy production system. It's like the difference between jump-starting a car with a dead battery versus actually replacing the battery.

What makes Thryve different from other NAD+ supplements?

Three key differences:

  1. Direct NAD+ delivery - We use pure NAD+, not just precursors that may not convert properly, especially during perimenopause when enzyme activity changes
  2. Female-specific formula - Includes quercetin to clear "zombie" cells that cause wrinkles, and resveratrol to activate longevity pathways
  3. Enhanced absorption - Our liposomal delivery system ensures the NAD+ actually reaches your cells instead of being broken down in your stomach

Safety and Side Effects

Is it safe to take long-term?

Yes. NAD+ is not a foreign substance—it's a molecule your body naturally produces. Clinical studies, including a landmark trial at Chiba University, have shown NAD+ supplementation to be safe for long-term use. In fact, maintaining healthy NAD+ levels is essential for healthy aging.

Are there any side effects?

The vast majority of women experience no negative side effects. In rare cases (less than 5% of users), some people report mild digestive upset when first starting. This typically resolves within a few days as your body adjusts. We recommend taking with food if you have a sensitive stomach.

Can I take this if I'm on other medications or supplements?

NAD+ is generally safe to combine with other supplements and medications. However, if you're taking prescription medications, especially blood thinners or diabetes medications, consult your healthcare provider before starting any new supplement regimen.

What if I'm pregnant or breastfeeding?

While NAD+ is naturally present in your body, we recommend consulting your healthcare provider before taking any supplements during pregnancy or breastfeeding.

Results and Timeline

How quickly will I see results?

Most women notice increased energy within the first 1-2 weeks. Skin improvements typically become visible around weeks 4-6. 

 

Deeper benefits like improved recovery, better sleep, and joint comfort often develop over 2-3 months as your cellular NAD+ levels rebuild.

 

Remember, this isn't a quick fix—it's restoring your cellular function, which takes time but creates lasting results.

What if I don't see results right away?

NAD+ works at the cellular level, so changes build over time. Some women with severely depleted NAD+ levels may need 4-6 weeks to notice significant improvements. We offer a 60-day money-back guarantee specifically because we know some women need more time to experience the full benefits.

Will the benefits go away if I stop taking it?

Your NAD+ levels will gradually return to their previous state if you stop supplementing, since the age-related decline continues. However, the cellular repair and improvements that occurred while taking Thryve don't instantly disappear—think of it like exercise. You'll maintain some benefits, but consistency gives you the best long-term results.

Dosage and Usage

How much should I take and when?

Take 2 capsules daily with your first meal. Taking with food helps with absorption and reduces any potential stomach sensitivity. 

 

Some women prefer taking both in the morning, while others split the dose (1 morning, 1 evening). Find what works best for your routine.

Can I take more than the recommended dose?

Stick to the recommended dosage. More isn't necessarily better with NAD+, and our formula is precisely dosed based on clinical research. Taking excessive amounts won't accelerate results and may cause unnecessary digestive upset.

Do I need to cycle off or take breaks?

No cycling necessary. NAD+ is something your body needs consistently, and the age-related decline is ongoing. Consistent daily use provides the best results for maintaining healthy cellular function.

Specific Health Concerns

I'm in perimenopause/menopause. Will this help with my symptoms?

Many of the symptoms women experience during hormonal transitions—fatigue, brain fog, poor sleep, mood swings—are actually related to declining NAD+ levels. 

 

Hormonal changes can accelerate NAD+ depletion, which is why we specifically formulated Thryve for women 40+. Many customers report improvements in energy, sleep quality, and mental clarity.

Will this help with my joint pain and stiffness?

While we can't make medical claims, the research on NAD+ and cellular repair is promising. Many customers report improved recovery and reduced stiffness. The quercetin in our formula has been studied for its effects on the enzymes that break down cartilage.

I have chronic fatigue. Is this different from other things I've tried?

If your fatigue is related to cellular energy production (which is common), NAD+ addresses the root cause rather than just masking symptoms. Many women with long-standing fatigue have found relief when other approaches failed, because this works at the mitochondrial level where energy is actually made.

Can this help with weight management?

NAD+ plays a role in metabolism, and many customers report improved energy for exercise and better sleep (both important for weight management).

 

 However, Thryve is not specifically a weight loss supplement—it's designed to restore cellular function, which can support overall health and vitality.

Ordering and Guarantee

How long does shipping take?

We offer free shipping on all orders, with standard delivery in 3-5 business days within the US. Express shipping options are available at checkout for faster delivery.

What's your return policy?

We offer a 30-day money-back guarantee. If you're not completely satisfied with your results, return the bottles (even if empty) within 60 days for a full refund. No questions asked.

Do you offer subscriptions or bulk discounts?

Yes! Our subscription program offers 15% savings and ensures you never run out. You can modify or cancel anytime. We also offer bundle discounts for 3 and 6-month supplies.

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Don't Let Another Year Slip Away

The women who feel and look 10 years younger than their age aren't lucky. They're not genetically blessed.

 

They just have one crucial advantage: their cells have the fuel they need to function properly.

 

You can have that same advantage.

References

1.https://www.cdc.gov/nchs/products/databriefs/db405.htm#:~:text=women%20than%20men.-,The%20age%2Dadjusted%20prevalence%20of%20osteoporosis%20at%20either%20the%20femur,higher%20among%20women%20than%20men.

2. https://www.mdpi.com/1422-0067/25/22/12139#:~:text=Likewise%2C%20androgens%20play%20a%20critical,and%20RANKL%2C%20which%20promote%20osteoclastogenesis.

3.https://www.spandidos-publications.com/10.3892/mmr.2017.6168#:~:text=OPG%2C%20which%20is%20a%20decoy,RANK%20(11%2C12).

4.https://pmc.ncbi.nlm.nih.gov/articles/PMC10608105/#:~:text=The%20RANK%E2%80%93RANKL%E2%80%93OPG%20System,%2C%20Immunity%2C%20and%20Cancer%20%2D%20PMC

5. https://www.longdom.org/open-access/postmenopausal-osteoporosis-causes-mechanisms-risks-diagnosis-treatment-and-prevention-guide1103308.html#:~:text=As%20bone%20mass%20declines%2C%20the,or%20even%20during%20daily%20activities.

6.https://pubmed.ncbi.nlm.nih.gov/35193674/

7.https://pmc.ncbi.nlm.nih.gov/articles/PMC12338550/#:~:text=Abstract,ATP%20generation%20through%20NADH%20oxidation.

8.https://pmc.ncbi.nlm.nih.gov/articles/PMC7442590/#:~:text=In%20humans%2C%20NAD%2B%20concentration%20has,as%20compared%20to%20newborns15.

9.https://pmc.ncbi.nlm.nih.gov/articles/PMC3139257/#:~:text=The%20mean%20age%20of%20this,group%20more%20than%2060%20years.

10. https://pubmed.ncbi.nlm.nih.gov/40053115/

11.https://www.endocrine.org/patient-engagement/endocrine-library/menopause-and-bone-loss#:~:text=Research%20indicates%20that%20up%20to,a%20fracture%20during%20their%20lifetime.

12. https://pubmed.ncbi.nlm.nih.gov/32564438/

13.https://pmc.ncbi.nlm.nih.gov/articles/PMC12338550/#:~:text=Loss%20of%20estrogens%20at%20menopause,the%20osteoclast%20lineage1%E2%80%934.https://pubmed.ncbi.nlm.nih.gov/32564438/

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