The Women’s Bone Health Institute

7 Reasons Women Over 55 Are Switching to Thryve’s Bone Support Formula 
(Even Those Who Tried Calcium, D3, or RX Options)

By Hannah Delaney | May 2025 | 6-minute read

Targets The Real Bottleneck Behind Bone Loss

Most supplements keep adding more calcium, even though your body can’t use it properly without enough cellular energy. Thryve focuses on supporting NAD+ pathways that influence bone remodeling — the part almost no doctor explains.

Works If You Take Calcium Or D3.

This is where most people get misled. Bone loss accelerates when your bone-building cells slow down. If your cellular energy is low, those nutrients can’t be fully utilized. Thryve acts more like the missing link that helps other bone nutrients do their job better. 

Supports Mobility, and Posture — Not Just “Density On A Scan.”

Most women don’t just want stronger bones — they want to move better, stand taller, and feel stable. Thryve’s approach activates the cells that actually build bone — osteoblasts. So it connects bone health to the things you actually experience day to day. 

Built For Postmenopausal Women (Not Generic “One-Size-Fits-all” Bone Pills).

Bone loss accelerates between ages 45 and 65. Thryve’s formula is designed around the biological realities women face during this stage of life. Instead of a generic blend that throws in random minerals and treats everyone the same, Thryve focuses on providing NAD+a molecule your body actually needs to support its natural bone-maintenance processes.

Avoids The Nightmre Calcium Megadoses 

Some women get stomach issues or worry about calcium depositing where it shouldn’t. Thryve focuses upstream — on the cellular processes that tell your body where to put minerals — rather than flooding you with more.

Fits Into A Routine That Pushes Long-Term Results

Once a day is all it takes. No complicated schedules, powders, or multi-step routines. Bone density changes slowly. What matters is daily consistency. Thryve is designed to be easy to stick to: one daily habit that supports your bone-building system from the inside out.

Safe, Allergen-Free, Third-Party Tested Clinically-Backed Ingredients

Thryve is manufactured in an FDA & GMP registered facility here in Denver. Our formula only contains 3 active ingredients and is 100% vegan, free from gluten, dairy,  and most common allergens. 

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Real Women Share Their Thryve Results

Overall Rating: 4.7/5 stars (Based on 274 reviews)

Even My Hairdresser Noticed!"

Even my hairdresser noticed how great my skin looked and couldn't believe I'm 57 years old. My afternoon fatigue is completely gone—I used to crash every day around 2 PM and now I have steady energy until evening.

Sarah M., 57, Retired Teacher

Verified Buyer

"Natural Energy Without Jitters"

But I must explain to you how all this mistaken idea of denouncing pleasure and praising pain was born and I will give you a complete account of the system, and expound the actual teachings of the great explorer of the truth

Lisa R., 42, Working Mom

Verified Buyer

"Better Sleep, Better Everything"

My sleep tracker shows significant improvement in deep sleep quality. According to my data, I feel like my circadian rhythm is back to a natural state. I've been having trouble sleeping for years due to shift work.

Jennifer T., 48, Nurse

Verified Buyer

"My Skin Texture Is Incredible"

The fine lines around my eyes have visibly softened, and people keep asking what I'm doing differently. I've been taking it for 4 months now and the changes just keep getting better.

Amanda C., 39, Personal Trainer

Verified Buyer

Frequently Asked Questions 

About NAD+ and How It Works

What exactly is NAD+ and why do I need it?

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every single one of your 30 trillion cells. Think of it as the "fuel" that powers your cellular engines (mitochondria), drives DNA repair, and activates longevity proteins called sirtuins.

 

After age 40, your NAD+ levels can drop by up to 50%, which is why you start feeling tired, recovering slower, and aging faster. It's not just "getting older"—your cells are literally running out of fuel.

How is this different from other energy supplements or vitamins?

Most energy supplements rely on stimulants like caffeine that give you a temporary boost followed by a crash. Thryve works at the cellular level to restore your body's natural energy production system. It's like the difference between jump-starting a car with a dead battery versus actually replacing the battery.

What makes Thryve different from other NAD+ supplements?

Three key differences:

  1. Direct NAD+ delivery - We use pure NAD+, not just precursors that may not convert properly, especially during perimenopause when enzyme activity changes
  2. Female-specific formula - Includes quercetin to clear "zombie" cells that cause wrinkles, and resveratrol to activate longevity pathways
  3. Enhanced absorption - Our liposomal delivery system ensures the NAD+ actually reaches your cells instead of being broken down in your stomach

Safety and Side Effects

Is it safe to take long-term?

Yes. NAD+ is not a foreign substance—it's a molecule your body naturally produces. Clinical studies, including a landmark trial at Chiba University, have shown NAD+ supplementation to be safe for long-term use. In fact, maintaining healthy NAD+ levels is essential for healthy aging.

Are there any side effects?

The vast majority of women experience no negative side effects. In rare cases (less than 5% of users), some people report mild digestive upset when first starting. This typically resolves within a few days as your body adjusts. We recommend taking with food if you have a sensitive stomach.

Can I take this if I'm on other medications or supplements?

NAD+ is generally safe to combine with other supplements and medications. However, if you're taking prescription medications, especially blood thinners or diabetes medications, consult your healthcare provider before starting any new supplement regimen.

What if I'm pregnant or breastfeeding?

While NAD+ is naturally present in your body, we recommend consulting your healthcare provider before taking any supplements during pregnancy or breastfeeding.

Results and Timeline

How quickly will I see results?

Most women notice increased energy within the first 1-2 weeks. Skin improvements typically become visible around weeks 4-6. 

 

Deeper benefits like improved recovery, better sleep, and joint comfort often develop over 2-3 months as your cellular NAD+ levels rebuild.

 

Remember, this isn't a quick fix—it's restoring your cellular function, which takes time but creates lasting results.

What if I don't see results right away?

NAD+ works at the cellular level, so changes build over time. Some women with severely depleted NAD+ levels may need 4-6 weeks to notice significant improvements. We offer a 60-day money-back guarantee specifically because we know some women need more time to experience the full benefits.

Will the benefits go away if I stop taking it?

Your NAD+ levels will gradually return to their previous state if you stop supplementing, since the age-related decline continues. However, the cellular repair and improvements that occurred while taking Thryve don't instantly disappear—think of it like exercise. You'll maintain some benefits, but consistency gives you the best long-term results.

Dosage and Usage

How much should I take and when?

Take 2 capsules daily with your first meal. Taking with food helps with absorption and reduces any potential stomach sensitivity. 

 

Some women prefer taking both in the morning, while others split the dose (1 morning, 1 evening). Find what works best for your routine.

Can I take more than the recommended dose?

Stick to the recommended dosage. More isn't necessarily better with NAD+, and our formula is precisely dosed based on clinical research. Taking excessive amounts won't accelerate results and may cause unnecessary digestive upset.

Do I need to cycle off or take breaks?

No cycling necessary. NAD+ is something your body needs consistently, and the age-related decline is ongoing. Consistent daily use provides the best results for maintaining healthy cellular function.

Specific Health Concerns

I'm in perimenopause/menopause. Will this help with my symptoms?

Many of the symptoms women experience during hormonal transitions—fatigue, brain fog, poor sleep, mood swings—are actually related to declining NAD+ levels. 

 

Hormonal changes can accelerate NAD+ depletion, which is why we specifically formulated Thryve for women 40+. Many customers report improvements in energy, sleep quality, and mental clarity.

Will this help with my joint pain and stiffness?

While we can't make medical claims, the research on NAD+ and cellular repair is promising. Many customers report improved recovery and reduced stiffness. The quercetin in our formula has been studied for its effects on the enzymes that break down cartilage.

I have chronic fatigue. Is this different from other things I've tried?

If your fatigue is related to cellular energy production (which is common), NAD+ addresses the root cause rather than just masking symptoms. Many women with long-standing fatigue have found relief when other approaches failed, because this works at the mitochondrial level where energy is actually made.

Can this help with weight management?

NAD+ plays a role in metabolism, and many customers report improved energy for exercise and better sleep (both important for weight management).

 

 However, Thryve is not specifically a weight loss supplement—it's designed to restore cellular function, which can support overall health and vitality.

Ordering and Guarantee

How long does shipping take?

We offer free shipping on all orders, with standard delivery in 3-5 business days within the US. Express shipping options are available at checkout for faster delivery.

What's your return policy?

We offer a 30-day money-back guarantee. If you're not completely satisfied with your results, return the bottles (even if empty) within 60 days for a full refund. No questions asked.

Do you offer subscriptions or bulk discounts?

Yes! Our subscription program offers 15% savings and ensures you never run out. You can modify or cancel anytime. We also offer bundle discounts for 3 and 6-month supplies.

To day’s offer:

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Don't Let Another Year Slip Away

The women who feel and look 10 years younger than their age aren't lucky. They're not genetically blessed.

 

They just have one crucial advantage: their cells have the fuel they need to function properly.

 

You can have that same advantage.

References

1.https://www.cdc.gov/nchs/products/databriefs/db405.htm#:~:text=women%20than%20men.-,The%20age%2Dadjusted%20prevalence%20of%20osteoporosis%20at%20either%20the%20femur,higher%20among%20women%20than%20men.

2. https://www.mdpi.com/1422-0067/25/22/12139#:~:text=Likewise%2C%20androgens%20play%20a%20critical,and%20RANKL%2C%20which%20promote%20osteoclastogenesis.

3.https://www.spandidos-publications.com/10.3892/mmr.2017.6168#:~:text=OPG%2C%20which%20is%20a%20decoy,RANK%20(11%2C12).

4.https://pmc.ncbi.nlm.nih.gov/articles/PMC10608105/#:~:text=The%20RANK%E2%80%93RANKL%E2%80%93OPG%20System,%2C%20Immunity%2C%20and%20Cancer%20%2D%20PMC

5. https://www.longdom.org/open-access/postmenopausal-osteoporosis-causes-mechanisms-risks-diagnosis-treatment-and-prevention-guide1103308.html#:~:text=As%20bone%20mass%20declines%2C%20the,or%20even%20during%20daily%20activities.

6.https://pubmed.ncbi.nlm.nih.gov/35193674/

7.https://pmc.ncbi.nlm.nih.gov/articles/PMC12338550/#:~:text=Abstract,ATP%20generation%20through%20NADH%20oxidation.

8.https://pmc.ncbi.nlm.nih.gov/articles/PMC7442590/#:~:text=In%20humans%2C%20NAD%2B%20concentration%20has,as%20compared%20to%20newborns15.

9.https://pmc.ncbi.nlm.nih.gov/articles/PMC3139257/#:~:text=The%20mean%20age%20of%20this,group%20more%20than%2060%20years.

10. https://pubmed.ncbi.nlm.nih.gov/40053115/

11.https://www.endocrine.org/patient-engagement/endocrine-library/menopause-and-bone-loss#:~:text=Research%20indicates%20that%20up%20to,a%20fracture%20during%20their%20lifetime.

12. https://pubmed.ncbi.nlm.nih.gov/32564438/

13.https://pmc.ncbi.nlm.nih.gov/articles/PMC12338550/#:~:text=Loss%20of%20estrogens%20at%20menopause,the%20osteoclast%20lineage1%E2%80%934.https://pubmed.ncbi.nlm.nih.gov/32564438/

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